Endocrine Abstracts

Introduction: The BsmI restriction fragment polymorphism of the vitamin D receptor (VDR) has been related with the development of bone disease in postmenopause, homozygous β thalassemia and hyperthyroidism. The present study aimed to evaluate the association between bone metabolism in patients with epilepsy and the BsmI VDR’s polymorphism.Methods/design: This cross-sectional study evaluated 73 adult patients with epilepsy, under antiepileptic d...

Introduction: Anti-epileptic drugs, usually defined according to their effect on the cytochrome P450 system, might lead to bone mineral density (BMD) decrease and fractures. The anticonvulsant valproate is a hepatic enzyme inhibitor, effective in many types of epilepsy. The present study aimed to assess the impact of long-term valproate monotherapy on BMD in a sample of consecutive ambulatory adult patients with epilepsy.Methods/design: This cross-sectio...

Introduction: Endogenous sex hormones may affect the cardiovascular risk profile in postmenopausal women indirectly by inducing metabolic, hemodynamic and immunological changes as well as directly through steroid receptors on the arterial wall. The results however, remain controversial.Objectives: This cross-sectional study aims to examine associations between circulating sex hormone levels and indices of vascular function and structure.<p class="abs...